Bill Ross demonstrates the relation between Gilles Deleuze’s philosophy of difference and the conceptual foundations of contemporary physics through careful engagements with the theory of relativity, quantum physics and chaos and complexity theory. Ross shows that recent work in cosmology by figures such as Lee Smolin and David Bohm calls into question the assumption that the laws of physics are universal and unchanging, a view that Deleuze anticipates. The second law of thermodynamics tells us that order in the universe as a whole is destined to break down. Against this, Ross demonstrates that, given Deleuze’s conception of the event as an expression of non-locality, and his emphasis on dissymmetry over symmetry, at the cosmological scale the universe is not destined towards disorder: evolution outruns entropy.