In this seminal study, Peter J. Katzenstein drags the analysis of world politics from the Newtonian humanism of the nineteenth century into a new post-Newtonianism of the twenty-first. The key concept is entanglement. By examining differences in context, process, and language, Katzenstein specifies how risk and uncertainty intertwine. Three deeply researched case studies – finance and political economy, nuclear crisis politics and war, and global warming and AI – support his original arguments. A chapter on power further illustrates the risk-uncertainty conundrum. Entanglements in World Politics calls for humility and eclectic pragmatism, emphasizing the unity of knowledge of the natural and humanistic sciences and the complementarities of science and religion. Katzenstein's engaging writing and innovative approach make this a must-read for anyone interested in the complexities of global politics. This book is also available as Open Access on Cambridge Core.